Formulation and Evaluation of Chrono Modulated Time Release Tablets of Metoprolol Tartrate
نویسنده
چکیده
The aim of the present work is to design an oral time release tablet by press coating method to achieve a distinct predetermined lag time. In this study Metoprolol tartrate was selected as the model drug. The outer shell was formulated with different weight ratios of Hydroxy propyl methyl cellulose K100M and Ethyl cellulose to achieve a release profile with pre determined lag time. The lag time was the time period referring no release followed by complete drug release. The lag time was significantly dependent on weight ratios of Hydroxy propyl metyl cellulose K100M and Ethyl cellulose. The best suited time lag was found of 6 hrs for formulation CM4. The predetermined time lag prior to the drug release from press coated tablets prepared by using EC and HPMC as a combination of retarding coating layer and gelling layer can be successfully employed for the formulation of press coated tablets.
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